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Table 1 Chromosomal aberrations in hepatocellular carcinoma (HCC) tumours compared to adjacent non-tumourous tissues (NT)

From: Gene networks and transcriptional regulators associated with liver cancer development and progression

Chr Arm Type of aberration Significanta Non-neoplastic tissues (NT) HCC
NT HCC Sizeb of intervals % cases affected Sizeb of intervals % cases affected
1 p – Loss Yes 0 0 407 27.3–31.8
1 q – Gain Yes 2108 7.7–23.1 2108 54.5–77.3
2 q – Gain Yes 0 0 206 27.3–36.4
3 p – Gain Yes 173 15.4–23.1 173 54.5–73.6
4 q – Loss Yes 0 0 689 27.3–31.8
5 p – Gain Yes 0 0 12 27.3
5 q – Loss Yes 0 0 673 27.3–31.8
5 q – Gain Yes 0 0 154 27.3
6 p – Gain Yes 525 7.7–15.4 1061 31.8–68.2
6 q – Loss Yes 0 0 26 27.3
7 p – Gain Yes 100 7.7–15.4 810 27.3–68.2
7 q Gain Gain Yes 96 23.1–30.8 146 36.4–72.7
7 q Gain Gain No 94 30.7–53.8 94 63.6–72.7
8 p – Loss Yes 103 7.7 525 31.8–63.6
8 q – Gain Yes 14 7.7 1456 27.3–50
8 q Gain Gain Yes 22 46.2 22 81.8
8 q Gain Gain No 54 38.4–69.2 54 72.7–81.8
9 q – Gain Yes 10 15.4 10 63.6
9 q Gain Gain No 276 30.7 276 63.6
10 q – Gain Yes 12 7.7 51 27.3–50
10 q – Loss Yes 0 0 13 27.3
11 q Gain Gain Yes 80 38.5 80 77.3
11 p/q Gain Gain No 373 38.4–53.8 373 59.1–72.7
12 p – Gain Yes 0 0 38 36.4
12 q – Gain Yes 323 15.4 323 54.5–63.6
13 q – Loss Yes 23 7.7 996 27.3–50.0
13 q – Gain Yes 21 7.7 21 45.5–50.0
14 q – Gain Yes 158 7.7–23.1 158 45.5–59.1
15 q – Gain Yes 38 15.4 498 27.3–54.5
16 p – Gain Yes 221 7.7 221 40.9–50.5
16 q – Loss Yes 15 7.7 15 31.8
17 p/q – Gain Yes 1802 7.7–15.4 1802 40.9–63.6
18 q – Loss Yes 0 0 759 27.3–36.4
19 q – Gain Yes 10 7.7 10 45.5
19 p Gain Gain No 652 53.8 652 68.2–77.3
19 q Gain Gain No 999 30.8–46.2 999 63.6–68.2
20 p/q – Gain Yes 820 7.7–23.1 1125 31.8–63.6
21 q – Gain Yes 0 0 235 27.3–36.4
22 q – Gain Yes 810 7.7–15.4 810 59.1–63.6
  1. The table only includes aberrations that spanned more than 10 probes. Known chromosomal imbalances in HCC are marked in bold. Common aberrations found in both HCC (n = 22) and adjacent NT (n = 17) samples were included when they affected > 50% of cases in one tissue set and > 30% of cases in the other; they are presented in italics
  2. Chr chromosome
  3. aDifferential aberrations between HCC and NT samples were considered statistically significant when P < 0.05 in differential aberration analysis
  4. bThe interval size is expressed as the total number of probes that spanned the aberration interval
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BMC Medical Genomics

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