Fig. 6
From: Multiple malignant tumors in a patient with familial chordoma, a case report
Potential effects of brachyury in promoting cancer aggressiveness. Over-expression of brachyury promotes cancer stemness and resistance to chemotherapy and radiation, and also enhances epithelial-mesenchymal transition, migration, invasion, and, eventually, metastasis. The mechanism is not well defined, but may relate to up-regulation of YAP transcription and stabilization of YAP protein by increased production of brachyury, with subsequent effects mediated primarily by YAP. This is an original figure